Applying vitamin B12 for a cofactor, folic acid can normalize large homocysteine amounts by remethylation of homocysteine to methionine via methionine synthetase.Atas penemuannya ini mendapatkan hadiah Nobel pada 1929. Hopkins tidak meneliti lebih jauh mengenai hal ini, kemudian penelitian ini dilanjutkan oleh Elmer McCollum, seorang ahli biokimia

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